Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 7th International Conference on Neurological Disorders & Stroke Rome, Italy.

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strokecongress@neurologyspeakerexperts.org
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Scientific Program Day 1
Scientific Program Day 2

Day 1 :

Keynote Forum

Gavin W Britz

Houston Methodist Hospital, USA

Keynote: Active regulation of CSF flow with the subarachnoid basal cisterns as one of the key regulators: a novel concept and review of the literature

Time : 09:30-10:10

Conference Series Stroke Congress 2018 International Conference Keynote Speaker Gavin W Britz photo
Biography:

Gavin W Britz earned his MBBCh Degree from the University of the Witwatersrand School of Medicine, Republic of South Africa (1987). He completed a surgical internship in general surgery and fellowship in general surgery at Johns Hopkins Hospital, Baltimore in 1993 and in 2002 he completed his residency in neurosurgery respectively. During his residency he attended St. Georges, University of London, UK (Medical School) and served as a Neurosurgical Registrar and Senior Registrar. After residency, he took a Cerebrovascular Fellowship in 2002 and an Interventional Neuroradiology Fellowship in 2003 at the University of Washington Medical School, Seattle. In 2003 he earned his MPH at the University of Washington, Seattle. He also obtained an MBA from George Washington University in 2015. He held faculty appointments at the University of Washington and Duke University before becoming a Member of Houston Methodist Research Institute in 2014

Abstract:

Background: CSF (Cerebrospinal fluid) has numerous physiological roles and its movement through the ventricular system and subarachnoid spaces is believed to be largely passive. The mechanisms, which maintain and modulate CSF flow are not completely understood. Objectives: We hypothesize that CSF flow is actively and strictly controlled/regulated by four major systems where the basal subarachnoid cisterns play a major role. Methodology: In anesthetized mice fluorophores (microspheres, 0.02 µm diameter or Alexa, 759 MW) injected intracisternally were allowed to circulate for one hour before brains were analyzed for fluorescence distribution. Tissue factor (TF) activity was blocked by specific antibodies injected intracerebroventricularly one hour before the fluorophores injection, non-specific IgG was used as control. Distribution of TF in the brain was explored with immunohistochemistry. Results: After the intracisternal injection of fluorophores, microspheres were distributed over 3±3% and Alexa were distributed over 21±14% of the ventral surface preferentially along the para-arterial spaces. Administration of TF antibodies one hour before the fluorophores injection increased spread of microspheres to 23±14% (p=0.03) and Alexa to 35±28% (p=0.04). Immunohistochemistry revealed expression of TF co-localized with GFAP immunoreactivity of glia limitans on the brain and ventricular surfaces. Conclusions: Our data supports the fact that active regulation of CSF flow occurs at least at the level of the basal cisterns as an inherent flow regulator. CSF flow is not just a passive flow of CSF after its secretion by choroid plexuses and ependyma in ventricular system. It is rather an extremely complex highly regulated system with multiple overlapping mechanisms involved.
 

Break: Networking & Refreshment Break: 10:10-10:30 @ Foyer

Keynote Forum

Abilash Haridas

St Joseph Children’s Hospital Tampa, USA

Keynote: Pediatric Moyamoya disease and neurosurgical management

Time : 10:30-11:10

Conference Series Stroke Congress 2018 International Conference Keynote Speaker Abilash Haridas photo
Biography:

Abilash Haridas completed his medical school and pursued his Postgraduate training in General Surgery at the Brooklyn Hospital Center in New York (USA). He switched career paths to Neurosurgery and spent a year at Harvard University. In 2006, he joined the prestigious Mount Sinai Hospital Neurosurgery Residency program in New York City, under the direction of Dr. Kalmon Post and Dr. Joshua Bederson. Following residency, he travelled to Chicago in 2011 for a Pediatric Neurosurgery Fellowship at Lurie Childrens Hospital of Northwestern University under the direction of Dr. Tadanori Tomita. In 2012 he completed an additional Cerebrovascular Fellowship at the University of Illinois in Chicago with Dr. Fady Charbel, specializing in complex cerebral bypass and aneurysm surgeries. He is currently the Chief of Pediatric Neurosurgery at St Joseph Children’s Hospital in Tampa, Florida (USA). He is a Pediatric Neurosurgeon specializing in cerebrovascular, skull base, endoscopic, and epilepsy surgery. In 2013, he joined the faculty at Wayne State University and Childrens Hospital of Michigan, bringing his rare expertise in pediatric cerebrovascular diseases. He is double fellowship trained in Pediatric and Cerebrovascular Neurosurgery. His interests are in all aspects of neurosurgery including Moyamoya, AVMs, aneurysms and skull base disorders. He has published in several leading journals and has lectured worldwide on a variety of topics in neurosurgery. His main clinical interest lies in translational neurosurgery and surgical technique improvement. 

Abstract:

Pediatric Moyamoya is a progressive neurological disorder in which the intracranial carotid arteries become slowly occluded leading to strokes. This can be especially debilitating in children leading to significant motor and cognitive delays in the young brain. There are some distinctive etiologies such as Down’s syndrome and Sickle cell disease which may lead to Moyamoya, especially in the younger population. Apart from medical management, the progressive natural history of this disease requires a multidisciplinary approach early to reduce future stroke morbidity. Early identification of symptoms of stroke in the very young can be difficult, and it is imperative to correctly identify Moyamoya as early as possible. Apart from the initial medical management, there are various surgical options which are all tailored to augment blood flow to the area of hypoperfusion in the brain. The surgical literature yields several options, all based on the severity of disease and is customized to each child. The revascularization options to the brain may be broadly divided into direct and indirect options, based on the age of the child and anatomical cerebral blood flow assessment based on MRI, CT angiography, and/or cerebral angiogram. The surgical technique varies based on surgical experience and long-term studies show good success with revascularization surgery.