Philip Anthony McMillan
University of Stirling, United Kingdom
Title: Integrated biochemical theory of delirium and experience with pharmacological reversal
Biography
Biography: Philip Anthony McMillan
Abstract
Delirium is a significant problem in older hospital admissions, with worse clinical outcomes, prolonged hospital stays and functional disability. This presentation will cover the clinical experience of managing these complex patients during their hospital stay. Looking at explaining an integrated theory of delirium, based on brain glutamate and ammonia management, the work aims to demonstrate the biochemical aspects of the condition. Anecdotal experience of reversing delirium using this biochemical framework and use of simple medication in hospital has been very successful with up to 70% of patients demonstrating clinical improvement. This theory has the potential to revolutionize our care of older patients and give insight into the links between delirium and dementia.